The missiles were launched from US Navy destroyers in the Mediterranean sea – the first use of Tomahawks by the US since November last year.
Trump said on Thursday he ordered a targeted military strike on the airfield in Syria from which a deadly chemical attack was launched.
Tomahawks were launched at 8:45 pm ET (1:45 am GMT), targeting the airfield’s hangers, aircraft, runways, and fuel storage areas.
The strike means Trump has taken more action against despot Bashar al-Assad in his first 77 days than Barack Obama used in six years while the war raged on in the region.
The number of deaths is yet to be confirmed, but sources within Syria have claimed the strikes caused “losses”.